5 Key Takeaways

• 1

  NAION is a challenging condition in ophthalmology with no widely used biomarkers for diagnosis or risk stratification.

• 2

  A study explored the atherogenic index of plasma (AIP) and triglyceride–glucose (TyG) index as potential biomarkers for NAION.

• 3

  Both AIP and TyG were significantly elevated in NAION patients compared to controls, despite normal traditional lipid parameters.

• 4

  The indices may indicate systemic metabolic vulnerability rather than acute optic nerve damage severity in NAION.

• 5

  Further prospective studies are needed to assess the predictive value of AIP and TyG for NAION and related vascular risks.