5 Key Takeaways

• 1

  In a mouse model of endotoxin-induced uveitis, neutrophil depletion increased retinal infiltration by CCR2-positive classical monocytes at 24 and 72 hours.

• 2

  Neutrophil depletion improved histologic measures of uveitis but did not significantly improve clinical scores.

• 3

  Anti-PECAM treatment significantly inhibited neutrophil and T-cell transmigration into the retina, with imaging showing neutrophils retained within retinal vessels.

• 4

  Compared with controls, anti-PECAM-treated mice had lower blinded clinical scores and less leukocyte infiltration, edema, and hemorrhage on histologic assessment.

• 5

  The preclinical study used an acute mouse model and administered anti-PECAM before symptoms developed, so its relevance to human uveitis remains undetermined.