Objective:

To explore the potential of optoretinography (ORG) as a non-invasive method for measuring photoreceptor function in vivo, highlighting its significance compared to traditional methods.

Key Findings:

• ORG can measure tiny changes in photoreceptor responses to light, which is crucial for understanding photoreceptor health.
• Recent developments have made ORG feasible for clinical use without exotic hardware, enhancing its accessibility.
• Advanced imaging techniques have clarified photoreceptor responses and support ORG's role as a biomarker, which is vital for future therapies.

Interpretation:

ORG offers a promising, objective method for assessing photoreceptor function, crucial for monitoring therapies and understanding photoreceptor health, potentially transforming clinical practices.

Limitations:

• ORG has not yet achieved broad acceptance in clinical practice, and significant challenges remain in standardizing stimuli and quantification metrics.
• Further validation is necessary to establish definitive clinical indications for ORG.

Conclusion:

ORG is poised for near-term clinical adoption but requires further validation and standardization before widespread use, emphasizing the need for continued research.