5 Key Takeaways

• 1

  Optoretinography (ORG) is a non-invasive method that measures photoreceptor function in vivo, complementing traditional structural imaging.

• 2

  ORG captures subtle changes in photoreceptor responses to light, allowing real-time visualization of cone and rod activity.

• 3

  Recent advancements have made ORG more clinically practical, utilizing modified fundus cameras and OCT systems without requiring specialized hardware.

• 4

  ORG is positioned to serve as a biomarker for photoreceptor physiology, aiding in patient stratification for clinical trials and monitoring treatment responses.

• 5

  Despite its potential, ORG requires standardization and broader acceptance before achieving definitive clinical indications.