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The Ophthalmologist / Issues / 2026 / January / Personalizing Corneal Cross-Linking
Cornea Opinions Research & Innovations

Personalizing Corneal Cross-Linking

How tailored approaches to CXL are transforming how we treat keratoconus and other corneal ectasias

By Emilio de Almeida Torres-Netto 1/12/2026 6 min read

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Objective:

To examine how personalized corneal cross-linking (CXL) is transforming clinical practice for corneal ectatic diseases, emphasizing its significance in improving patient outcomes.

Key Findings:
  • Epi-on CXL protocols have been developed to minimize risks while maintaining epithelial integrity, showing promise in clinical outcomes.
  • Corneal optimization before cataract surgery can enhance IOL calculation accuracy, leading to better refractive outcomes.
  • Customized CXL combined with excimer laser treatment can significantly improve visual outcomes in irregular corneas, demonstrating the effectiveness of personalized approaches.
Interpretation:

Personalized CXL approaches allow for tailored treatment strategies that enhance both corneal stability and visual quality across various patient scenarios, ultimately improving patient outcomes.

Limitations:
  • Epi-on CXL may still lag behind epi-off in certain biomechanical effects, and further research is needed to fully understand its long-term efficacy.
  • Clinical outcomes depend on careful patient selection and adherence to advanced protocols, which may pose challenges in real-world settings.
Conclusion:

Personalized CXL represents a significant advancement in treating corneal ectatic diseases, offering improved safety and visual outcomes, and highlighting its transformative potential in clinical practice.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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