4 Topic Commentaries

Combination Therapy Targets Bacterial Keratitis

Combination Therapy Targets Bacterial Keratitis

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  Nisha R. Acharya, MD, MS

  Ophthalmology (Uveitis/Cornea)

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  University of California, San Francisco (UCSF) Department of Ophthalmology

  “We consider this finding very significant; it’s a clinically meaningful difference,” said the paper’s co-author Nisha Acharya, MD, MS, associate professor and director of the Uveitis Service in the UCSF Department of Ophthalmology. Although secondary to the study’s original purpose, Acharya said the results in severe cases were identified early on, so “we didn’t start doing all of these analyses after the fact. It was of interest. So I think there is something there.”

  Source
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  Nisha R. Acharya, MD, MS

  Ophthalmology (Uveitis/Cornea)

  •

  University of California, San Francisco (UCSF) Department of Ophthalmology

  “It’s important to note that in the worst ulcer group, not only do we not find a safety problem, we actually found that steroids resulted in a benefit in vision,” Acharya said. “So I think that is really reassuring because those were the people with whom we were most scared to use steroids.”

  Source
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  Nisha R. Acharya, MD, MS

  Ophthalmology (Uveitis/Cornea)

  •

  University of California, San Francisco (UCSF) Department of Ophthalmology

  “There was no increase in cornea perforations in our patient population,” Acharya said. “I’m reassured to know that it’s not associated with harm.”

  Source
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  Nisha R. Acharya, MD, MS

  Ophthalmology (Uveitis/Cornea)

  •

  University of California, San Francisco (UCSF) Department of Ophthalmology

  “It makes us feel like we’re moving towards an evidence-based paradigm of care for corneal ulcers rather than a trial and error sort of approach,” Acharya said. “We have a good collaboration and now that we’ve had some success with this, we hope to be able to continue with it to answer other questions related to this field.”

  Source