Objective:
To evaluate the effectiveness of combining low-dose atropine with Defocus Incorporated Multiple Segments (DIMS) spectacle lenses for myopia control in children.
Key Findings:
- Axial elongation at 12 months was 0.18 mm in the atropine-only group compared to 0.07 mm in the combination group, a statistically significant difference of 0.11 mm.
- Nearly 40% of children receiving combination therapy showed no axial elongation, compared to 12% in the control group.
- Changes in spherical equivalent refraction (SER) were directionally favorable but not statistically significant.
Interpretation:
Limitations:
- The study represents an interim analysis of a 24-month trial, with longer-term data needed to confirm durability of effect.
- Questions remain regarding optimal atropine dosing and comparison with other strategies.
Conclusion:
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